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130 In BMSCs and preosteoblast MC3T3-E1 cells, miR-376b-3p directly targets YAP1 to suppress YAP1 expression, and circ_0024097 serves as a ceRNA to rescue YAP1 by absorbing miR-376b-3p, leading to activation of the Wnt/-catenin signalling pathway and cell differentiation, which attenuates osteoporosis

545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA

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