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Of the 1,283 screened individuals, 223 men and women were enrolled, ranging in age from 18 to 85 years

Genetic variants in the CAIS1 gene that encodes NLRP3 are associated with an increased relative risk of ME/CFS

Thus, oxidative stress occurs when the production of reactive oxygen species (ROS) outweighs the body's ability to detoxify them [8]

J Neurochem (2018) 146(2):17385

68 Reduction of serum ammonia level and improvement in performance on neuropsychological testing, 69 improvement in energy levels, general functioning and well-being, and reduction of anxiety and depression, 70 reduction of physical and mental fatigue, 71 and improvement of cognitive deficits and EEG findings 71 in these studies were limited by small number of participants, high risk of bias, and low power for detection of meaningful differences between the treatment groups