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In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

While the absolute risk remains lowestimated at 0.3% to 0.5% over 20 years of usefurther investigations are needed to confirm whether similar risks exist for Wegovy, Ozempics counterpart for obesity treatment