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Exposure to pemetrexed is increased in patients with mild to moderate renal impairment who take concomitant ibuprofen, increasing the risks of adverse reactions of pemetrexed

In having said that I suffered bradycardia and tachycardia previously but my mind set was fast heart rate makes me susceptible to tachy and so the increase was a worry for me

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However, it is crucial to emphasise that these findings derive predominantly from animal models and have not been conclusively demonstrated in human clinical practice