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10.1111/mmi.12030 135 Van LaerK.HamiltonC

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FIGURE 4 3.1 Modulation of inflammatory signaling pathways 3.1.1 Inhibition of nuclear Factor- B (NF- B) pathway Glycyrrhizin exerts anti-inflammatory effects and directly protects hepatocytes by regulating genes such as interleukin-4 (IL-4), fibroblast growth factor 10 (FGF10), inhibiting Inhibitor of kappa B (I B) phosphorylation and p65 nuclear translocation to suppress NF- B activation in hepatocytes, thereby reducing the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) (Figure 4)