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Our structural analysis maps these two residues to a turn in the S tail, suggesting that the Ser1261Ala/Glu1262Ala double mutation modifies the conformational accessibility of the extended motif and reduces coatomer binding

The FDA issued warnings in 2025 about compounded GLP-1 drugs arriving warm during shipping with inadequate refrigeration, which compromises drug quality

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Sigalos and Pastuszak 2018, a review of the growth hormone secretagogue class covering GHRH analogs and GH-releasing peptides, concluded that these compounds are generally well tolerated but flagged decreased insulin sensitivity and elevated blood glucose as a consistent signal across the class, alongside a call for more long-term data on cancer incidence with sustained use