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If your aim is to reduce cardiovascular disease, restricting its use to a limited time only and for those with the highest BMIs doesnt make sense. The SELECT trial enrolled 17,604 adults aged 45 years and older with a BMI of 27 kg/m2 or higher and established atherosclerotic CVD

Additionally, GLP-1 helps with satiety, or the feeling of fullness, which can aid in reducing food intake

Certain medical historiesincluding a family history of thyroid cancer or specific endocrine conditionsmay rule it out entirely

36 Although no major qualitative sex differences have been identified in the mechanisms of action of GLP-1 receptor agonists, quantitative variations in treatment response and adverse effects have been reported, potentially influenced by interactions with sex hormones such as estrogens

Understanding the realistic outlook helps with planning