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Why GLP-1s Cause Cold Sensitivity Many people taking GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) or liraglutide (Victoza, Saxenda) report feeling persistently cold, though this is not listed as an official adverse effect

Older adults may experience slower metabolic rates, which could impact weight loss outcomes

Pharmaceutical GLP-1s flood your system with synthetic hormones to override your natural signals - which can lead to nausea, fatigue, bloating, or other less-than-fun side effects

M.et al (2016)

Keep a blanket accessible at your desk or on your couch, and don't hesitate to wear socks, a hat, or gloves indoors if neededthis is temporary and completely normal