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Zikry et al.1 conducted a systematic literature review, yielding 23 cases with scrotal melanoma and found that tumor presented as stage I/II disease 18.75% of the time, stage III 56.3% of the time, and stage IV 25% of the time, whereas typical cutaneous melanoma presents as stage I/II disease 84% of the time

This data was collected as part of a clinical study conducted by us, described in Acharya et al

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This interaction results in cAMP signaling which in turn stimulates transcription of MITF (microphthalmia- associated transcription factor) [5]

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