[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Argano C., Colomba D., Di Chiara T., La Rocca E
The reasons for the differences in effectiveness in different cancer cell lines remain unexplained as neither the cellular accumulation of the prodrug nor the expression of the Tb HGPRT gene can justify the differences in cytotoxicity observed among the tested cell lines [158]
Subsequent studies support this hypothesis, as the presence of SBP2 in an in vitro translation system was found to decrease G418-mediated read-through of susceptible UGA-containing transcripts (151)
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Patients with a history of gastrointestinal disorders, including inflammatory bowel disease, gastroparesis, or previous pancreatitis, should maintain closer communication with their healthcare provider throughout Zepbound treatment, as they may be at higher risk for complications