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3.2.1 NF- : a central player in inflammation and cancer Both innate and adaptive immunity depend greatlyon NF-, a major regulator of inflammatory reactions

and patients with glutathione-S-transferase M1 (proinflammatory-cytokine producer macrophages) null and M1 and T1 (Type 1 helper CD4 + lymphocytes) double null polymorphisms had increased mortality suggesting that antioxidant therapy becomes fundamental for those patients (109)

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While B12 is available in oral supplements, absorption can vary greatly

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