In fact, the gene encoding the catalytic subunit of GCL ( GCLC ) is under the control of the antioxidant-responsive element (ARE), promoting the binding of the major detoxification-involved transcription factor (TF), nuclear factor erythroid 2-related factor 2 (Nrf2) [20]
Neither approach is universally "better" they're different strategies, and the metabolic field is actively pursuing both in parallel
The 4-Week Rule: You typically increase the dose only every 4 weeks , moving toward a maintenance dose (e.g., 1.72.4 mg) if needed and tolerated
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