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Chris Masterjohn wrote an excellent review of this study and proposes other interesting possibilities, including gender differences and vitamin deficiency issues

The Study Doesnt Prove GLP-1s Cause Osteoporosis or Gout Because the study was observational, it cannot determine whether GLP-1 medications directly caused the increased rates of bone issues or gout

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Using our proteomics data set, we confirmed an IF- and p53-mediated upregulation of proteins representing general macrophage markers (CD68, LYZ2 and RAC2 (Fig