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A case report of a patient with HER2-expressing NEPC with rapid progression on seven different lines of therapy demonstrated substantial response on off-label treatment with T-DXd, including a 57% overall reduction in tumor volume across sites of metastases and improved performance status 171

It acts directly on neighboring -cells to inhibit the secretion of glucagon and can also indirectly influence -cells by inhibiting the secretion of other hormones

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These compounds work together to support the bodys natural resilience from multiple angles