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BED is characterized by eating large amounts of food, often quickly and to the point of discomfort

-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

Ganeshan K, Chawla A (2014) Metabolic regulation of immune responses

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All these actions contribute to better blood sugar control and reduced appetite