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P., Joanette, Y., Wang, H., Comas-Herrera, A., Alessi, C., Suharya, K., Mwangi, K

Slow titration is used specifically to let the gut adapt and limit nausea

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al

Frederick, J., Fletcher, H., Simeon, D., Mullings, A

The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%