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Proliferative pathways Tuberous sclerosis (TS) is a monogenic disorder with a high prevalence of ASD that is caused by LoF mutations in the TSC1 and TSC2 genes [115]

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Inflammation of the body occurs with a poor diet (rich in unhealthy fats, added sugar and processed food), smoking, hormonal imbalance, sleep issues, obesity, stress, and a multitude of auto-immune-related conditions

Conversely, persistent appetite, continued craving, or weight regain may indicate that psychological, behavioural, environmental, or treatment-exposure factors are overriding satiety-related effects, especially because weight regain can occur after treatment withdrawal or interruption (95)