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The tamoxifen-induced mitochondrial stress has been attributed to its inhibition of complex I and III of the mitochondria electron transport complexes (mETC) [46,47,48] and a consequent increase of intracellular ROS in both ER- + and ER-- cells [49]

Low testosterone contributes to reduced libido and poor sexual performance

The effect of ghrelin thermoregulation is mediated by the arcuate nucleus and vagus nerve The hypothalamic arcuate nucleus is one of the target tissues of ghrelin involved in stimulation of appetite and feeding behavior

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The FAK-paxillin pathway is central to cell adhesion, migration, and proliferation