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In preclinical research settings, NNMT modulation is investigated for its downstream influence on NAD + -related biochemical pathways and cellular energy regulation

The compound's high membrane permeability and metabolic stability make it suitable for both acute and chronic study designs, but researchers should be aware that its effects on NAD+ and methylation metabolism may require time to fully manifest

So the 100% figure is an assumption from how systemic administration generally behaves, not a measured number for this compound

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