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Two major clinical trials are the basis for most of what's known about these medications' weight-management effects: STEP 1 (68-week randomized study, adults without diabetes): semaglutide 2.4 mg produced an average loss of roughly 15% of body weight, versus about 2.4% with placebo, alongside a reduced-calorie diet and increased physical activity

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As one of the stimulators for the CPT system, the PPAR family is also present in the endothelium

Some patients report mild digestive discomfort or temporary skin lightening with injection

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