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The absence of published bioavailability studies, coupled with theoretical limitations, suggests that berberine patches are unlikely to deliver therapeutically relevant amounts of the compound into systemic circulation

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MSM+Vit C group (8 mg/Kg of MSM plus 5 mg/Kg of vitamin C, daily) and Control (no supplementation)

Interestingly, though products like Ozempic and Mounjaro are indicated for T2D like SGLT2s, the distribution of claims by payer channel differs between the classes