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While these trials excluded patients with a formal diagnosis of type 2 diabetes, its highly plausible that a substantial proportion of participants had early metabolic abnormalities, such as insulin resistance , elevated fasting insulin , or even undiagnosed prediabetes

Thus, weak detoxification of the RAN/tobacco metabolites by GSTP1 Ile/Ile leads to higher induction of oxidative damages to DNA leading to mutagenesis and genomic instability

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Receiver operating characteristic curve analysis The receiver operator characteristic (ROC) curve and the area under the curve were calculated with MetaboAnalyst 5.0 ( software

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