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Efficacy of NNMT inhibitor 5-amino-1MQ in diet-induced obese (DIO) mice 17-week old, male DIO C57Bl/6 mice that have been fed high-fat diet (HFD) for 11 weeks (starting at week 6) were purchased from Jackson Labs (Jackson Laboratory

ACS Chemical Neuroscience 14 (4): 527553

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While Tirzepatide often produces greater total weight loss than AOD-9604 , it also carries a more complex side effect profile including nausea, vomiting, and gastrointestinal distress

Monitoring Schedule: Initial phase: Weekly or monthly monitoring Maintenance phase: Periodic monitoring (e.g., every 3-6 months) By watching these lab results and making dosage changes as needed, doctors can tailor B12 therapy for each patient