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Injectable vitamin B12, which can treat significant deficiencies, may cause the following common side effects: More serious side effects of vitamin B12 injections can include: irregular heartbeat heart palpitations hives or a skin rash Vitamin B12 can cause very rare but serious allergic reactions, or anaphylaxis

That being said, not all B vitamins are equal

Cost Implications for B12 Injections Understanding Costs Under Part B Under Part B, after meeting the annual deductible, Medicare generally pays 80% of the approved amount for B12 injections, leaving beneficiaries responsible for the remaining 20%