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Patients who discontinue their medication tend to regain a significant portion of the lost weight within 12 months, as the biological signals that drive appetite and weight regain return

Emerging metabolites, such as succinate, also modulate immune-inflammatory processes and oxidative stress in the cardiovascular system, reflecting the growing complexity of microbiotacardiovascular interactions [43]

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Finally, the PLB dosage and administration strategy should be refined, and its long-term effects and potential side effects should be comprehensively evaluated to confirm its safety and effectiveness in clinical applications

While Ozempic is not FDA-approved for weight management, it is sometimes used off-label for this purpose due to its ability to reduce appetite and promote weight loss