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6 Conclusion and outlook The intricate ferroptosis-immune-metabolic axis has emerged as a central driver of COPD pathogenesis, creating a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

Notably, gemcitabine and anthracycline-based immunogenic chemotherapy are particularly beneficial when used in conjunction with NAM in preclinical models of pancreatic and breast carcinoma (83)

This type of metabolic-induced cell death is called glutamoptosis, which supports a tumor suppressor role of glutamine metabolism and mTORC1 (normally known as pro-proliferative inducers) during nutritional imbalance