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Background On February 28, 2024, Vivani announced positive preclinical weight loss data from its exenatide implant in support of its NPM-115 development program which was comparable to semaglutide injections (the active pharmaceutical ingredient in Ozempic/Wegovy) and a strategic shift to prioritize its obesity portfolio

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However, these effects were found to be reversible when sleep fragmentation occurred intermittently [209, 210]

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Rotate injection sites and refrain from repeatedly injecting hexarelin into the same site due to risk of scarring and hardening of fatty tissue, which can interfere with peptide absorption [20]