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"Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes." JAMA Netw Open

Large molecules dont easily cross intestinal walls designed to absorb small nutrients

Ros program fee covers support, but medication is billed separately and prices for brand-name GLP-1s can be steep without insurance

It carries a boxed warning regarding the risk of thyroid C-cell tumors observed in rodent studies and should not be used by individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, during pregnancy, or where otherwise contraindicated

The addition of the C-18 fatty acid moiety to Lys26 is hypothesized to increase the binding dose-response ratio due to an increased albumin affinity