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33 Similar findings were observed in a meta-analysis of 40 trials which concluded that GLP-1RAs were highly effective at lowering circulating glucose levels without causing hypoglycemia

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For weight management in people without diabetes , NICE recommends considering semaglutide 2.4 mg (Wegovy) for adults with a BMI 35 kg/m (or lower thresholds for certain ethnic groups) and at least one weight-related comorbidity