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Tumor microenvironment as a therapeutic target in cancer

As integral components of the NVU, perivascular astrocytes maintain BBB characteristics by contributing to basement membrane formation, regulating pericyte differentiation, and modulating EC functions by regulating the expression of TJs such as claudin-5, occludin, and ZO-1 [49, 51,52,53]

Anti-inflammatory effect TB-500 reduces the expression of the pro-inflammatory cytokines TNF- and IL-1 in several preclinical models of tissue injury

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