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PGE 2 contributes to pain hypersensitivity and hyperalgesia by lowering pain thresholds and by enhancing nociceptor sensory fiber excitability by activating EP1-EP4 receptors on nociceptors [91,112]

Summary of studies integrating populationlevel data with in vitro and in vivo experiments

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The commenter requested that CMS equalize payment between PD catheter procedures and vascular access procedures to avoid possible disincentives to home treatment and provide patients with additional quality care options

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