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Gil-Mohapel J, Brocardo PS, Choquette W et al (2013) Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brain

This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

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