Until more evidence is available, in this individualized risk and benefit decision-making, one should not assume that this risk is specific to semaglutide. Taken in total, the summary noted that currently available evidence suggests a possible association between semaglutide and NAION
These considerations highlight the need for future studies specifically designed to evaluate GLP-1RAs in patients at high risk of PsA, particularly those with subclinical inflammation or early musculoskeletal symptoms
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We compared a 6 and 12-month change in total body weight loss (TBWL) for those receiving monotherapy from the initiation of GLP-1 analogue therapy with those receiving combination therapy from the initiation of bupropion/naltrexone added-on therapy