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Although the use of GLP-1 RAs prior to EGD or colonoscopy has resulted in poor outcomes in terms of poor visibility/preparation scores and the need for aborted/repeated procedures, one study showed better outcomes with concurrent EGD and colonoscopy

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For gut healing, direct mucosal contact is part of the mechanism

A review published in Regulatory Toxicology and Pharmacology stated that the evidence of safety is strong at intakes up to 2000mg/day l-carnitine equivalents for chronic supplementation. The authors went on to note that taking higher levels had not shown any safety risks

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