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Importantly, there are risks for certain populations, especially if individuals are not carefully followed by a health care professional

Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]

Clinical trials have extended beyond two years, and the safety profile appears acceptable for ongoing use

Previous in vitro and in vivo experiments have shown that erianin induces cell cycle G2/M phase arrest, apoptosis and autophagy in human osteosarcoma cells by activating the reactive oxygen species (ROS)/JNK signaling pathway and serves an anticancer role (72)

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