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The numbers speak for themselves

Moving the tongue, talking, or swallowing during this period reduces absorption

Never take metformin on an empty stomach, as this dramatically increases the chance of GI side effects

2 These include: Nausea Diarrhea Vomiting Constipation Abdominal pain or discomfort Decreased appetite (an intended effect, but can be excessive for some) Burping (eructation) Indigestion (dyspepsia) Gastroesophageal reflux disease (GERD) These side effects are typically mild to moderate in severity, are most common when starting the medication or increasing the dose, and often lessen over time as the body adjusts

For example, weight reduction can lead to better testosterone levels in men, which can enhance their libido and erectile function