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TNF could decrease hepatocyte sensitivity to insulin by reducing the expression of glucose transporter 4 (GLUT4) and by reducing the phosphorylation of insulin receptor substrate 1 (IRS1) [130]
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A minimum of 150 minutes of moderate aerobic exercise per week is sufficient to meet the threshold of the recommended level, and this may include fast walking, cycling, or swimming
Topical forms might cause rashes in sensitive individuals
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