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New knowledge on the precise aberrations in the Wnt pathway in association with ROS and NF-B signaling may lead to more effective treatments by specifically targeting -catenin, the -catenin destruction complex, or the TCF transcription factor

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Weight loss is the most visible change, with clinical trials demonstrating average reductions that vary by medication: approximately 5-10% with liraglutide (Saxenda), 15-17% with semaglutide 2.4mg (Wegovy) in the STEP trials, and up to 20% with higher doses of tirzepatide in the SURMOUNT programme