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Two features of that founding experiment matter enormously and are almost always dropped in summaries

Bone Marrow: Composition and Hematopoiesis expansion Extramedullary hematopoiesis Extramedullary Hematopoiesis Primary Myelofibrosis hepatomegaly and/or splenomegaly Splenomegaly Splenomegaly is pathologic enlargement of the spleen that is attributable to numerous causes, including infections, hemoglobinopathies, infiltrative processes, and outflow obstruction of the portal vein

Klein J, Kppen A, Lffelholz K

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Despite results from a low-confidence subgroup analysis, higher doses and longer courses of treatment may yield greater benefits without causing serious side effects