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However, these diseases are difficult to treat given their complexity and the challenges of drug delivery to the brain [10, 11]

Dose optimization represents the first-line approachescalating to 1 mg weekly, and subsequently to 2 mg weekly for diabetes management or 2.4 mg weekly for weight management, often produces substantially better outcomes than remaining at 0.5 mg

10.1080/15569543.2020.1747495 6 AlsubaieiS

These drugs could achieve weight loss approaching or exceeding 25%, further transforming treatment expectations

Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation