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This is achieved by a rapid increase in cAMP, which is accompanied by direct activation of PKA and EPAC

doi: 10.4049/jimmunol.166.7.4456 135 GuYBartolome-CasadoRXuCBertocchiAJanneyAHeubergerCet al

10.1016/j.neuint.2012.11.009 Neurochem Int

The crucial role of the substantia nigra dopaminergic neurons in operant conditioning for food emerged from data showing that selective restoration of dopamine production in substantia nigra or its primary terminal target, the dorsal striatum, is sufficient to restore the motivation to work for food in mice that lack dopamine otherwise (Sotak et al., 2005