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Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established

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The H protein then shuttles this methylamine group to the T protein, which catalyzes the transfer of the methylene group (CH 2 ) to tetrahydrofolate, forming 5,10-methylenetetrahydrofolate

10.1016/j.bone.2017.07.028 43 KimH