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However, the fact that the potentially clinically beneficial food reward suppressing effects of GLP-1R stimulation can be disassociated from the clinically undesirable nausea offers promise for a future therapy selectively targeting the mesolimbic reward system GLP-1R populations that could be free of this most common adverse effect of GLP-1 analog therapy

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Therefore, it is recommended that IGF-1 levels remain within the upper normal range (+1 to +2 SDS) for age-matched normal children during GH therapy, and it is indicated in infants and children with PWS to start therapy with a daily dose of 0.5 mg/m2 per day to minimize side effects, with subsequent adjustments toward 1.0 mg/m2 per day (117)

10.1016/j.apsb.2022.08.015 27 DurgadeviP.GirigoswamiK.BoseD.ThirumalaiA.HariniK.KiranV.et al (2026)