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Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks

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Clinical trials for both mazdutide and retatrutide have not shown elevated rates of pancreatitis, but the sample sizes and durations are still relatively small compared to the decades of post-market surveillance available for older medications

Next, a handpiece is glided over the skin as energy is delivered into the deeper layers of the skin

The combination has shown faster wound closure and improved skin elasticity in clinical settings