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With proper agent selection, patient monitoring, and team-based care, GLP1s can be safely and effectively used in this complex population

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The most valuable property of the orobuccal mucosa is that drugs that can be absorbed, enter the systemic circulation directly by passive transport

Conversely, individuals with obesity show increased oxygen consumption in the insula, operculum, bilateral precuneus, and posterior cingulate cortex, along with the ventral putamen and Rolandic operculum, but decreased oxygen uptake in the lower caudatepatterns associated with increased impulsivity towards food stimuli (128130)