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doi:10.1371/journal.pone.0035240

However, uncontrolled type 2 diabetes may lead to potentially serious health issues

In this narrative review, we thoroughly trace the current preclinical and clinical evidence of seven pain modalities, including inflammatory pain, osteoarthritis, visceral pain, neuropathic pain, diabetic neuropathy, cancer pain and headache, to support the efficacy and underlying biological mechanisms of GLP-1RAs as therapeutic agents for pain suffering

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IGF-1R Binding and Downstream Signalling IGF-1 LR3 remains a full agonist of the IGF-1 receptor, with very low affinity for IGFBPs making it more potent than unmodified IGF-1 in cell culture and pre-clinical models