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Under hypoxic conditions, the activity of cytoplasmic prolyl-hydroxylases is inhibited, preventing the hydroxylation and subsequent ubiquitination of HIF-1, enhancing the stability of HIF-1

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The first interaction interface, termed Interface , occurs along the same spiral line, where two adjacent SNX1 dimers interact through contacts between the 2 helix and 3 helix of the BAR domain (Fig

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