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May 22 2025;13(6)doi:10.3390/biomedicines13061275

Colchicine-loaded hydrogel microneedles demonstrate prolonged anti-inflammatory efficacy by downregulating pro-inflammatory cytokines (IL-1, IL-6, and TNF-) and reducing neutrophil infiltration in gouty joints, as evidenced in rat arthritis models (Jiang et al., 2023)