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C32 is the second active-site cysteinyl residue of PfGrx and C88 is the third cysteinyl residue, which is in the proximity of the active site and can also undergo redox modifications 14,26,30

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Among the betalains, betanin (betanidin 5-O-b-D-glucoside) is a major phytochemical representative, a water-soluble nitrogen heterocyclic compound that gives the BR a red-violet color (182)

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Oral intake of 2,400 mg/day for two weeks was also found to be safe in a pilot study that included participants with multiple sclerosis (95)