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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

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doi: 10.1016/0006-291X(88)90674-2 120 WallrappABurkettPRRiesenfeldSJKimSJChristianEAbdulnourREEet al

The G150 series compounds targeting the ATP/GTP-binding pockets of human cGAS demonstrate potent inhibitory activity in THP-1 cells [413], and compound S3, identified through molecular dynamics simulations and virtual screening, exhibits a mechanism of action analogous to PF-069282155 [414]